Atovaquone - d4 for hydroxyl 1, 4 - naphthalene, quinoline, is the homologue of the coenzyme Q is the activity of several kinds of parasite. On plasmodium, the role of parts for cytochrome BCL point (point Ⅲ). Atovaquone - d4 reversibility and can combine with peptides on 11500 da molecular group. Dihydrogen orotic acid dehydrogenase is important enzymes in the biosynthesis of pyridine, through coenzyme Q connecting mitochondrial electron transport, hence Atovaquone - d4 by inhibiting the electron transfer to prevent the synthesis of pyridine. Some metabolic enzymes through coenzyme Q in the mitochondrial electron transport, therefore, Atovaquone - d4 inhibitory effect of electron transfer is actually inhibits the activity of these enzymes.
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