The amalgam and in vitro antimicrobial appraisal of several quinoline and pyrimidoquinoline derivatives are described. Treatment of 7-substituted quinolin-2(1H)-one-3-carboxylic acids 2a-c with phosphoryl chloride or thionyl chloride gave acceleration to the Quinoline-3-carboxylic acid 3a-c and 7-substituted 2-chloro-3-chlorocarbonylquinolines 5a-c respectively. The 2-chloro action in compounds 3a-c was replaced by 2-aminothiazole or 2-aminopyridine to accord 2-(thiazol-2-yl)aminoquinoline-3-carboxylic acids 4a-c or 2-(pyrid-2-yl)aminoquinoline-3-carboxylic acids 4d-f. Treatment of 5a-c with the aforementioned heterocyclic amines at allowance temperature furnished the agnate 7-substituted 2-chloro-3-heteryl-aminocarbonylquinolines 6a-f. The tetracyclic 9-substituted thiazolo[3', 2':1, 2]-pyrimido[4, 5-b]quinolin-5-ones 7a-c and 10-substituted pyrido[1', 2':1, 2]-pyrimido[4, 5-b]quinolin-6-ones 7d-f were actinic by heating 5a-c with the heterocyclic amines in toluene or by heating 6a-f beneath abatement in dimethylformamide. The articles were evaluated in vitro for abeyant antimicrobial activity.
More about:Quinoline-3-carboxylic acid manufacturer
No comments:
Post a Comment