Prucalopride is a careful 5-HT4 receptor agonist, with a serotonin enterokinetic activity. The receptor has a role in gastrointestinal activity disorders such as annoyed bowel affection and idiopathic constipation.
5-HT4 receptor GPCR, which are bidding in the CNS and in borderline tissues. Prucalopride has pK (I) ethics of 8.60 and 8.10 for the animal 5-HT (4a) and 5-HT (4b) receptor are, and at atomic 290-fold selectivity for 5-HT4 over added serotonin and dopamine receptors.
Prokinetic agonists and abeyant use in diseases with bargain mobility. Prucalopride is a careful 5-HT4 receptor agonists, serotonin enterokinetic activity.
more about: Prucalopride
from: Pharmaceutical Ingredients
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