What is the role of Triamterene

What is the role of Triamterene? For many people this may be unfamiliar, and here's the introduction to it:

Ammonia benzene pteridine, used in the treatment of various types of edema, such as heart failure, liver cirrhosis and chronic nephritis caused by edema and ascites, and glucocorticoid treatment during water sodium retention. They are often used in combination with potassium diuretics. It is also used in the case of the case of hydrochlorothiazide or spirate.

The potassium diuretic agent for potassium diuresis is similar to that of snail, but its mechanism is different from that of the latter. It is not aldosterone antagonists, but direct inhibiting renal distal convoluted tubule and collecting duct of Na + in epithelial cells, and then change across the membrane potential, and to reduce the secretion of the K +; The resorption of Na + reduces the amount of Na +, Cl - and water excretion, while K + excretion decreases. The effect is more rapid, but weaker, is an inefficient diuretic, and its potassium is weaker than the snail. Oral absorption is rapid, but not completely, and the bioavailability is about 30% ~ 70%. 2 hours after oral, tmax is 6 hours and lasts 12 to 16 hours. T1/2 is 1.5 to 2 hours, but the non-urinator's t1/2 is significantly longer, up to 10 hours. This product is metabolized in the liver, the original form and metabolite are excreted mainly by the kidney, the minority passes through the bile duct. Animal experiments show that the product can be secreted through the placenta and secreted into milk.