Appearance: white or almost white powder or crystalline powder, odorless, tasteless, soluble in water, insoluble in ethanol, acetone, ether, chloroform; easy to decompose when exposed to light.
Carboplatin is a second-generation platinum compound, in 1986 in the UK, and its biochemical and physical characteristics similar to cisplatin, but nephrotoxicity, ototoxicity, neurotoxicity, especially gastrointestinal reactions was significantly lower than the DDP, widespread attention in recent years, new drugs, and DDP belong to the cell cycle non-specific drugs. It is the main role of DNA guanine N7 and O6 atoms, causing DNA chains and chain crosslinking damage DNA molecule helix melting prevent its interfering with DNA synthesis, and cytotoxicity.
Carboplatin as a broad-spectrum anti-tumor, with no cross-resistance to other antineoplastic agents, with DDP cross-resistance, easy to dissolve the drug, without hydration, hydration Lee, diuretic, easy to use.
(1) is mainly used for small cell lung cancer, ovarian cancer, testicular cancer, head and neck squamous cell carcinoma and so on. Small cell lung cancer, the FDA response rate was 60% single; with Vp-16, IFO combination therapy overall response rate was 78%; epithelial ovarian cancer, head and neck squamous cell carcinoma alone produced remission rates were 65%, 29%.
(2) can be used for non-small cell lung cancer, bladder cancer, cervical cancer, pleural mesothelioma, melanoma and endometrial cancer.
(3) can also be used for digestive system cancer, liver cancer therapy and radiation efficiency.
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From:Natural herbal extracts
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