EPL(EPLERENONE) is a selective aldosterone receptor antagonist, it only applies to the mineralocorticoid receptor, and not acting on the androgen and progesterone receptors. EPL treatment 1 and 2 hypertensive patients, efficient and lower systolic and diastolic blood pressure with enalapril similar magnitude. Angiotensin converting enzyme inhibitors and angiotensin Ⅱ receptor inhibitor effect of poor low renin levels in patients with essential hypertension, EPL also has a good antihypertensive effect. For isolated systolic hypertension has a good antihypertensive effect of diet-induced obesity-related hypertension have a good antihypertensive effect. In addition, EPL can significantly reduce glomerular ultrafiltration, reduce albuminuria in patients with hypertension, for hypertensive patients with diabetes, renal protective effect of this is more obvious.
Indications:
1, acute myocardial infarction, congestive heart failure after: eplerenone can improve left ventricular dysfunction (ejection fraction ≤ 40%) the quality of life of patients, clinical trials demonstrate that the product can also be used for heart failure after acute myocardial infarction after acute myocardial infarction, congestive heart failure;
2, anti-hypertension: Eplerenone may be used alone or with other antihypertensive drugs in combination for the treatment of hypertension.
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From:Natural herbal extracts
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