English name: Toll-Like Receptor 11 Polyclonal Antibody,Toll-like receptor 11 (TLR 11) is a protein encoded by the gene TLR11. TLR 11 belongs to the Toll-like receptor (TLR) family and the Interleukin-1 receptor/Toll-like receptor superfamily. By recognizing flagellin and/or profilin present on certain microbes, it helps propagate a host immune response. TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha, the Interleukin 12 (IL-12) response, and Interferon-gamma (IFN-gamma) secretion. TLR11 mounts an immune response to multiple microbes, including Toxoplasma gondii (T. gondii), Salmonella species, and uropathogenic Escherichia coli (E. coli), and likely many other species due to the highly conserved nature of flagellin and profilin.
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