What is the Anti-DDC ( DOPA decarboxylase )?

Anti-DDC（DOPA decarboxylase） is an agitator alive in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in abounding analytic disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to anatomy L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to anatomy dopamine. This neurotransmitter is begin in altered areas of the academician and is decidedly abounding in basal ganglia. Dopamine is aswell produced by DDC in the affectionate afraid arrangement and is the forerunner of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the afraid system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving acceleration to serotonin. DDC is a homodimeric, pyridoxal phosphate abased enzyme.

Anti-DDC（DOPA decarboxylase） is a accumulation II decarboxylase that catalyzes the decarboxylation of ambrosial L-amino acids. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. Deficiency of DDC is associated with astringent adorning delay, oculogyric crises and autonomic dysfunction. It is an about 104 kDa protein that belongs to the aspartate aminotransferase ancestors (fold blazon 1) of PLP-dependent (vitamin B6-dependent) enzymes. The catalytically alive anatomy of the agitator exists as a homodimer, archetypal of this chic of enzymes.The homodimeric anatomy of the agitator antiseptic from sus scrofa is apparent in circuitous with the inhibitor carbidopa to the right.

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From: Elisa assay kits

Introduce the Anti-C-Peptide ( C-PEP )

In adjustment to access Anti-C-Peptide ( C-PEP ), is acclimated to a specific antigen, again injected into the beastly body, and again from the beastly serum amid adapted antibiotic method. The antibodies acquired by this method, not alone the crop is low, and the antibiotic specificity, low purity, acknowledgment acute enough. People begin in animal, action during allowed responses, in vivo B corpuscle can accomplish up to a actor or added specific antibodies, but anniversary B beef bury a actinic backdrop of a single, able specificity antibody. In adjustment to get a ample amount of individual antibody, have to use a individual B corpuscle carbon cloning, i.e.. Compared with accepted antibodies, monoclonal antibodies, top yield, able specificity, top sensitivity, the ahead is actual obvious. Pro-Insulin consists of the three parts: C-peptide and two continued strands of amino acids ( alpha and beta chains; after become affiliated calm to anatomy the Insulin atom every atom of ). From Pro-Insulin, one atom of Insulin additional one atom of C-peptide are produced. C-peptide is appear into the claret beck in according amounts to Insulin.

Anti-C-Peptide ( C-PEP ) should be kept at a low temperature, continued time apparent to air, agreeable will be reduced. Storage at -20 ℃. Antibiotic is the capital action and antigen (including adopted and self) combined, thereby finer removing invasive in vivo microbial, parasites and added adopted matter, and they absolution toxins or abatement of assertive autoimmune antigen, accomplish the physique to advance accustomed balance, but sometimes on the physique acquired by dissection damage, such as antinuclear antibody, anti bifold abandoned DNA antibodies, thyroglobulin antibiotic and added autoantibodies produced, on the animal physique can could cause a harm. The antibiotic C-PEP-01 reacts accurately with C-peptide, a allotment of the Proinsulin molecule.Proinsulin consists of the three parts: C-peptide and two continued strands of amino acids ( alphaand beta chains, after become affiliated calm to anatomy the Insulin atom .No cross-reactivity with Insulin or ) added peptide hormones or proteins was observed.

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From: Elisa assay kits