Tuesday, July 30, 2013

Policresulen on the application in gynecology




Gynecological medicine: Policresulen is a new drug treatment of cervical erosion, non-toxic, does not cause allergies and drug resistance of diseased tissue necrosis or selective, enabling condensation off the diseased tissue, but also causing local congestion, stimulate granulation tissue proliferation, accelerate skin coverage, but does not damage normal tissue. This product is also through high acid and protein coagulation and kill bacteria, mold and trichomoniasis, and has astringent, hemostatic effect. For the treatment of cervical erosion, vaginal variety of inflammatory or bleeding after biopsy. Can also be used to treat small burns, limb ulcers, bedsores and chronic dermatitis.
Uses various hospital departments a list of situations:
Gynecological medicine: for the treatment of cervical erosion, cervicitis, various vaginal infections (such as bacteria, mold and mildew caused by Trichomonas increased vaginal discharge), genital itching, caused by the use of a pessary pressure ulcers and cervical polyps after resection or biopsy hemostasis.
Surgery and Dermatology: Skin wounds and lesions for local treatment (such as burns, limb ulcers, bed sores, chronic inflammation), can accelerate the shedding of necrotic tissue, bleeding and facilitate the healing process.
ENT: used to treat inflammation of the oral mucosa and gums, mouth ulcers and bleeding after tonsillectomy.
Adverse reactions: medication early local irritation were seen, but soon go away. When policresulen for oral lesions, should pay attention to their high acidity can damage tooth enamel.


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Sunday, July 28, 2013

Salinomycin saodium prospects



Salinomycin saodium of monocarboxylic polyether animal-specific antibiotics, the majority of Gram-positive bacteria and a variety of coccidia have strong inhibitory and killing effect, easy to produce drug resistance and cross-resistance, rapid excretion, residual very low for pigs can prevent diarrhea, promote growth, improve the survival rate, mainly for poultry against coccidiosis U.S. researchers found a way to "targeting" and kill cancer stem cells compounds in the laboratory during the study period, the kill mice effectiveness of breast cancer stem cells than normal anti-cancer drug Taxol (Taxol) 100 times higher. Salinomycin saodium the body can not only kill cancer cells in mice, they also inhibit tumor cell gives rise to new, existing while slowing tumor growth.

Application Prospects:
With the accelerated pace of economic globalization, China has also been a rapid development of animal husbandry. Accelerate the export of livestock and poultry products, the promotion of Chinese rural problems, and promote comprehensive development of China's economy has major significance. However, more and more antibiotics are widely used in the treatment and prevention of various diseases of livestock, drug residues in animal products that affect international trade an important factor. Some Western industrial countries on antibiotics in animal products increasingly strict requirements, food of animal origin detection of antibiotic residues, has become the world meat trade in important technical indicators and one technical barriers.
China lags behind the development, large-scale livestock farming is not high, feeding and management level is low, the dosage is not standardized, the withdrawal of other problems, drug residues difficult to achieve the requirements of developed countries, leading to difficult access to developed country exports of livestock and poultry products of the market, even some veteran has entered the international market leading products are also forced to withdraw. This issue has become a constraint on China's export of animal products bottleneck.
Therefore, in the aquaculture industry select low toxicity and residue, broad-spectrum antibiotics, is the key to solve this bottleneck. While domestic quality medicines is still less than the current total feed salinomycin gap of 11,000 tons; China is a major exporter of antibiotics, one in Europe and enjoys a high reputation in the market, there are also considerable international market demand; salinomycin production process is relatively Simple, easy to master technology, the use of agricultural products and raw materials are all ordinary simple inorganic raw materials, non-toxic and harmless; Therefore, salinomycin breed development is conducive to people's livelihood, is the veterinary profession of veterinary drugs currently irreplaceable species.



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Friday, July 26, 2013

Some of the human placenta extracts.




Human placental medical scientists found, human placenta andcarnivorous almost. The difference is, contains a variety of vitamins and enzymes in human placenta, such as follicle stimulating hormone, luteinizing hormone, prolactin, lysozyme,kininase, protease. Main functions: 1, anti infection effect of placental gamma globulin containing measles, influenza antibodyand diphtheria antitoxin, can be used to prevent or reducemeasles and other infectious diseases. Because of the protein, sooral invalid, must injection. Placental gamma globulin also contains interferon, clinical on can be used for the prevention orcontrol of viral infection. The placenta also contain lysozyme, can prevent mice (i.p.) caused by enteritis of death
Enhance the body resistance to mice orally: placenta powder, can reduce tuberculosis lesions, and in vitro can promote the growthof Mycobacterium tuberculosis, so that its main function is toincrease the body resistance. Hydrochloric acid hydrolysis product of placenta after degreasing, rats were given intraperitoneal injection of carbon tetrachloride and B, caused by sulfur amino acid based liver fat deposition, has the obvious inhibitory action.Mice were given a subcutaneous injection of human placenta extracts, can prolong the swimming time of rats; intramuscular injection, on some experiments (reserpine, tonic, pylorus ligationlower) experimental ulcer, also have the effect of preventing and treating certain
In vitro, placenta extract can promote recovery of inhibited the heart. Placental protein, containing a pressor substance reninkind, in the regulation of blood circulation, and its significanceremains to be further elucidated. Human placenta is aglycoprotein containing ingredients, in vitro, inhibition oflymphocyte DNA synthesis, but does not affect cell viability.Heating the placenta extract can inhibit the methamphetaminecaused a great deal of time. Refrigerated placental pepsin digestion liquid, water extract and 70% acetone extract withWarburg apparatus sensing, respiratory and yeast could promote the liver, heart, brain and several kinds of tissue respiration is not frozen, refrigerated effect strong. Placenta Serum excitatory effect on the isolated guinea-pig uterus, similar posterior pituitary hormone. Chorionic villi of placenta extract is significant for cancer patients compared to healthy skin reaction, has certain diagnosticvalue, can continue to study, improve its specificity.



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From:Natural herbal extracts

Thursday, July 25, 2013

For Mouse Tumor necrosis factor αTNF-α ELISA KIT brief description of the



Name: Mouse Tumor necrosis factor αTNF-α ELISA KIT
Description: This immunoassay kit allows for the in vitro quantitative assurance of abrasion TNF-α concentrations in serum, claret and added biological fluids.The ancestor ligand of the TNF superfamily, TNF-α/TNFSF1A, is a pleiotropic cytokine that plays a axial role in deepening and apoptosis. It is actinic as a 26 kDa, blazon II transmembrane protein that is 233 amino acids in length. It contains a 30 amino acerbic (aa) cytoplasmic domain, a 26 aa transmembrane segment, and a 177 aa extracellular region.



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Wednesday, July 24, 2013

Megestrol acetate Preparation and Application



Megestrol acetate as progestin on pituitary gonadotropin releasing a certain extent, but more than levonorgestrel and norethindrone weak. Does not have estrogen and androgen-like activity, but there are obvious anti-estrogen effect. In combination with estrogen to suppress ovulation. Animal teratogenicity study in rabbits showed that the stillbirth rate has increased and teratogenic effects.
Preparation:
Method name: megestrol acetate - Determination of megestrol acetate - High Performance Liquid Chromatography
Application: This method uses HPLC megestrol acetate content. This method applies to megestrol acetate.
Principle of the method: the test sample was dissolved in methanol and diluted to a certain concentration of the solution into the liquid chromatographic separation with UV absorbance detector at the wavelength of 288nm at the detection of megestrol acetate absorption value, calculate its content.
Reagents:
1 methanol (HPLC grade)
2 water (HPLC grade)
Equipment:
1 instruments
1.1 HPLC
1.2 Columns: octadecylsilane bonded silica as a filler, number of theoretical plates megestrol acetate peak should not be less than 2000.
1.3 UV absorption detector
2 chromatographic conditions
2.1 Mobile phase: methanol: water = 70 30
2.2 detection wavelength: 288nm
2.3 column temperature: room temperature
Sample Preparation:
1 standard solution: take megestrol acetate amount, accurately weighed, set 100 mL volumetric flask, dissolved in methanol and diluted to the mark, shake, the precise amount 2mL, set 10 mL volumetric flask, dissolved in methanol and diluted to the mark, shake.
2  Preparation of the test solution: take megestrol acetate 20mg, accurately weighed, in 100 mL flask, dissolved in methanol and diluted to the mark, shake, the precise amount 2mL, set 10mL volumetric flask, dissolved in methanol and diluted to the mark, shake.
Steps: precision drawing reference solution and the test solution 10μL injection high performance liquid chromatography with UV absorbance detector at the wavelength of 288nm at the determination of the absorption of megestrol acetate, calculate its content.

Application:Oral
1 treatment of amenorrhea, 1 4mg, 2 to 3 times a day, even serving 2 to 3 days, stopping 2 to 7 days, that withdrawal bleeding.
(2) the treatment of functional bleeding, a second 4mg, every 8 hours, once every three days reduction, reduction does not exceed the original dose of 1/2 until the daily maintenance dose of 4mg, a total of 20 days.
3. The treatment of endometriosis, a second 4mg, 2 times a day for 7 to 3 times a day after each 4mg, 7 to 2 times a day at a later date. 1 8mg, and then served on the 7th, and then increased to a daily 20mg, 6 weeks for a course of treatment.
4 breast cancer, a sub-40mg, 4 times a day, the daily amount of 160mg, for 2 consecutive months.
5 endometrial cancer, 1 10 ~ 80mg, 4 times a day, the daily amount of 40 ~ 320mg, or one 160mg, day 1.
[Preparation and specification] megestrol acetate tablets: ① 4mg; ② 160mg.



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From:Hormones product

Loteprednol and pharmacological efficacy


Name: Loteprednol
English name: Loteprednol Etabonate
English Synonyms: androsta-1 ,4-diene-17-carboxylic acid, 17 - [(ethoxycarbonyl) oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (8xi, 9xi, 11beta, 14xi, 17alpha) -; Chloromethyl (8xi, 9xi, 11beta, 14xi, chloromethyl (11beta, 17alpha) -17 - [(ethoxycarbonyl) oxy]-11-hydroxy-3-oxoandrosta-1 ,4-diene-17-carboxylate [1]
CAS :82034-46-6
Formula: C24H31ClO7
Molecular Weight: 466.9517
Indications: For the treatment of the eye cornea, conjunctiva and anterior segment inflammation
ACTION: loteprednol (Loteprednol etabonate) is a new type of glucocorticoid drugs. Loteprednol ophthalmic suspension 0.2% (Alrex) for the treatment of seasonal allergic conjunctivitis; 0.5% (Lotemax) applies to the eyelids and bulbar conjunctiva, cornea and eye front steroid-sensitive treatment of inflammation , such as: allergic conjunctivitis, keratitis, erythema, superficial punctate keratitis, herpes zoster keratitis, iritis, iridocyclitis, selective infectious conjunctivitis.
Cortisol has a good anti-inflammatory drugs, but also accompanied by the treatment of toxicity occur, for people trying to find low toxicity cortisol drugs. Loteprednol as "soft drugs" is based on the principles of research design Bodor solve the problem of drug toxicity cortisol, while the characteristics of strong anti-inflammatory has been further strengthened. With prednisolone different loteprednol easily hydrolyzed to inactive acid, when used in the eye, and rapidly metabolized to inactive products, reducing the systemic toxicity, and anti-inflammatory effect of prednisolone is more than strong.



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From:Natural herbal extracts

Sunday, July 21, 2013

What is Repertaxin L-lysine salt?



Cas No.: 446024-42-6
R-(-)-2-(4-Isobutylphenyl)propionyl methansulphonamide L-lysine salt
Repertaxin is a new non-competitive allosteric acquaintance of interleukin-8 (CXCL8/IL-8) receptors (CXCR1/R2), which by locking CXCR1/R2 in an abeyant anatomy prevents receptor signaling and animal polymorphonuclear corpuscle (PMN) chemotaxis. Given the different approach of activity of repertaxin it was important to appraise the adeptness of repertaxin to arrest a advanced ambit of biological activities induced by CXCL8 in animal leukocytes. Our after-effects appearance that repertaxin potently and selectively blocked PMN adherence to fibrinogen and CD11b up-regulation induced by CXCL8.



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Wednesday, July 17, 2013

The Esametilentetrammina Products



Esametilentetrammina is a white hygroscopic crystalline powder or colorless shiny diamond crystals, combustible. Melting point 263 ℃, such as melting point that exceeds this sublimation and decomposition, but does not melt.

Product Use

1 hexamethylene tetramine mainly used plastic resin and a curing agent, a catalyst and a blowing agent aminoplast, rubber vulcanization accelerator (accelerator H), textiles shrink agent.
2 hexamethylene tetramine organic synthesis of raw materials, in the pharmaceutical industry for the production of chloramphenicol.
3 hexamethylene tetramine urinary system can be used as a disinfectant, which itself has no antibacterial effect on gram-negative bacteria. A 20% solution for the treatment of underarm odor, sweaty feet, tinea and so on. It is mixed with sodium hydroxide and phenol, phosgene gas masks do absorbent.
4 and used in the manufacture of pesticides. Hexamethylene tetramine with fuming nitric acid can be obtained highly explosive RDX, referred to as RDX.
5 hexamethylene tetramine can be used as determination of bismuth, indium, manganese, cobalt, thorium, platinum, magnesium production, lithium, copper, uranium, beryllium, tellurium, bromide, iodide and other reagents and reagent chromatography . [2]
Hazard Overview

Risk category:
Pathways: Health Hazard: production conditions, the main cause dermatitis and eczema. Pleomorphic rash, itching, beginning limited contact area, the future can spread throughout the body even.
Environmental hazards:
Explosion hazard: The product is flammable, corrosive, can cause the body burns, exposure can cause dermatitis, itching.

First aid measures
Skin contact: Remove contaminated clothing, use soap and water thoroughly washed skin.
Eye contact: Did eyelid, mobile or saline irrigation water. Doctor.
Inhalation: rapidly from the scene to fresh air. Keep the airway patency. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Doctor. Ingestion: drink plenty of water, induce vomiting. Doctor.
Fire-fighting measures

Hazardous characteristics: case of fire, cause a fire hazard. Thermal decomposition of the toxic release of nitric oxide gas. Mixed oxidants and can form explosive mixtures. Corrosive.
Hazardous combustion products: carbon monoxide, carbon dioxide, oxides of nitrogen.
Fire fighting methods: water cooling containers, if possible to move containers from the scene empty Department. Extinguishing Media: Foam, carbon dioxide, water spray, sand.

Emergency treatment: ACCIDENTAL RELEASE: isolation leakage polluted area, restricting access. Cut off the fire source. Recommended emergency personnel wearing a dust mask (full cover), wear protective clothing. Do not direct contact with leakage. A small leak: clean shovel collection in a dry, clean, covered containers. Large Leak: plastic sheeting, canvas cover. Use non-sparking tools to collect recycling or shipped to the waste disposal sites.

Disposal Storage: Handling Precautions: closed operation, local exhaust ventilation. The operator must go through specialized training, strict adherence to rules. Proposed operators wear self-absorption filter respirators, wearing chemical protective safety glasses, wear protective overalls on infiltration. Keep away from fire, heat, workplace smoking. Use explosion-proof ventilation systems and equipment. Avoid generating dust. Avoid contact with oxidizing agents, acids. Handling of light when light unloading, packaging and containers to prevent damage. Equipped with the appropriate variety and quantity of fire equipment and emergency equipment leakage. Empty containers may be harmful residues.

Storage Precautions: Store in a cool, ventilated warehouse. Keep away from fire and heat. Sealed packaging. Should oxidants, acids stored separately and avoid mixing reservoir. Explosion-proof lighting, ventilation facilities. Prohibit the use of easy to produce sparks of mechanical equipment and tools. Storage areas should be equipped with suitable host material spill.



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From:herbal extracts

Monday, July 1, 2013

Pharmacological effects of ambroxil HCL

Ambroxil HCL blueprint C13H18Br2N2O · HCL, achromatic and cellophane liquid. It can advance respiratory centralized adhesive fungus secretions to abate exclusion and retention, and appropriately decidedly advance expectoration. For beard associated with aberrant and expectoration of sputum dysfunction in astute and abiding respiratory disease. This artefact has a role in announcement and abandoning fungus secretions exclusion of features, it can advance respiratory centralized adhesive fungus secretions to abate exclusion and retention, and appropriately decidedly advance expectoration, advance breath conditions. FDA should therapy, the accommodating fungus beard recovered to accustomed condition. Ahem and sputum is usually a cogent abridgement in the respiratory amplitude film apparent alive substances which can play its accustomed careful function. For accompanied by aberrant beard of fungus and expectoration dysfunction in acute, abiding respiratory diseases, such as: astute exacerbations of abiding bronchitis, asthmatic bronchitis, bronchial asthma, expectorant treatment; postoperative pulmonary complications in pre- hair treatment; preterm accouchement and bairn breed with respiratory ache affection (IRDS) treatment. Ambroxol Hydrochloride and Glucose Injection is usually able-bodied tolerated, balmy high gastrointestinal ancillary furnishings appear occasionally (mainly abdomen heartburn, indigestion and casual nausea, vomiting). Allergic acknowledgment rarely occurs, mainly rash, rarely appear cases of astringent astute allergic reaction, but with ambroxol alternation is not certain, some of which patients are usually aswell allergic to added substances. This artefact can not be aloft pH 6.3 was alloyed with other, as pH increases would aftereffect in precipitation of the chargeless abject ambroxol. Preclinical trials and afterwards 28 weeks of abundance for a ample amount of analytic acquaintance has apparent that the artefact has no adverse aftereffect on pregnancy. But during pregnancy, abnormally in the aboriginal trimester should be acclimated with attention drugs, drugs can access the milk, but the ameliorative dosage had no cogent aftereffect on the baby.

Ambroxil HCL with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) can be added antibacterial accessory ameliorative concentrations in the lung tissue, in aggregate with added drugs, no clinically accordant adverse reactions were reported. This artefact is currently the a lot of broadly acclimated analytic expectorant. Can activate the accumulation of the respiratory amplitude and the surfactant adjustment aqueous and mucinous secretion, which can advance the respiratory cilia breadth and non-ciliated arena of the abolishment effect, abbreviation the adherence of sputum and cilia, added easier to ahem the phlegm, and abate ahem phenomenon. Since the aftereffect of this artefact bound indeed, well-tolerated, abiding use, it is an ideal accomplished expectorant medicine. Rapid articulate assimilation of the biologic completely, 0.5-3 hour claret absorption accomplished its peak. Single articulate dosage of the biologic 30mg, beggarly aiguille claret absorption (Cmax) was 88.8ng/ml, mainly in the lung, liver, kidney, claret protein bounden is 90%. Bioavailability of about 70% -80%. The biologic is mainly metabolized in the liver, 90% austere by the kidneys, metabolite anthranilic acerbic bromide, its biological action is not clear. Half-life of 7 hours. 72 hours afterwards articulate administration, about 70% of the urinary excretion, whether by milk beard is unclear. For accompanied by aberrant beard of fungus and expectoration dysfunction of astute and abiding lung disease. For example, astute deepening of abiding bronchitis, asthmatic bronchitis and bronchial asthma expectorant treatment. Pulmonary complications afterwards surgery, antitoxin treatment. Premature accouchement or neonatal respiratory ache affection (IRDS) treatment. This artefact is usually able-bodied tolerated. Had balmy gastrointestinal adverse reactions reported, mainly for abdomen heartburn, indigestion and casual abhorrence and vomiting. Allergic acknowledgment rarely occurs, mainly rash.

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