Name: Repertaxin L-lysine salt
Cas No.: 446024-42-6
R-(-)-2-(4-Isobutylphenyl)propionyl methansulphonamide L-lysine salt
Repertaxin is a new non-competitive allosteric acquaintance of interleukin-8 (CXCL8/IL-8) receptors (CXCR1/R2), which by locking CXCR1/R2 in an abeyant anatomy prevents receptor signaling and animal polymorphonuclear corpuscle (PMN) chemotaxis. Given the different approach of activity of repertaxin it was important to appraise the adeptness of repertaxin to arrest a advanced ambit of biological activities induced by CXCL8 in animal leukocytes. Our after-effects appearance that repertaxin potently and selectively blocked PMN adherence to fibrinogen and CD11b up-regulation induced by CXCL8.
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