Name: Loteprednol
English name: Loteprednol Etabonate
English Synonyms: androsta-1 ,4-diene-17-carboxylic acid, 17 - [(ethoxycarbonyl) oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (8xi, 9xi, 11beta, 14xi, 17alpha) -; Chloromethyl (8xi, 9xi, 11beta, 14xi, chloromethyl (11beta, 17alpha) -17 - [(ethoxycarbonyl) oxy]-11-hydroxy-3-oxoandrosta-1 ,4-diene-17-carboxylate [1]
CAS :82034-46-6
Formula: C24H31ClO7
Molecular Weight: 466.9517
Indications: For the treatment of the eye cornea, conjunctiva and anterior segment inflammation
ACTION: loteprednol (Loteprednol etabonate) is a new type of glucocorticoid drugs. Loteprednol ophthalmic suspension 0.2% (Alrex) for the treatment of seasonal allergic conjunctivitis; 0.5% (Lotemax) applies to the eyelids and bulbar conjunctiva, cornea and eye front steroid-sensitive treatment of inflammation , such as: allergic conjunctivitis, keratitis, erythema, superficial punctate keratitis, herpes zoster keratitis, iritis, iridocyclitis, selective infectious conjunctivitis.
Cortisol has a good anti-inflammatory drugs, but also accompanied by the treatment of toxicity occur, for people trying to find low toxicity cortisol drugs. Loteprednol as "soft drugs" is based on the principles of research design Bodor solve the problem of drug toxicity cortisol, while the characteristics of strong anti-inflammatory has been further strengthened. With prednisolone different loteprednol easily hydrolyzed to inactive acid, when used in the eye, and rapidly metabolized to inactive products, reducing the systemic toxicity, and anti-inflammatory effect of prednisolone is more than strong.
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From:Natural herbal extracts
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