Thursday, December 27, 2012

What is the Anti-DDC ( DOPA decarboxylase )?


Anti-DDC(DOPA decarboxylase) is an agitator alive in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in abounding analytic disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to anatomy L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to anatomy dopamine. This neurotransmitter is begin in altered areas of the academician and is decidedly abounding in basal ganglia. Dopamine is aswell produced by DDC in the affectionate afraid arrangement and is the forerunner of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the afraid system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving acceleration to serotonin. DDC is a homodimeric, pyridoxal phosphate abased enzyme.

Anti-DDC(DOPA decarboxylase) is a accumulation II decarboxylase that catalyzes the decarboxylation of ambrosial L-amino acids. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. Deficiency of DDC is associated with astringent adorning delay, oculogyric crises and autonomic dysfunction. It is an about 104 kDa protein that belongs to the aspartate aminotransferase ancestors (fold blazon 1) of PLP-dependent (vitamin B6-dependent) enzymes. The catalytically alive anatomy of the agitator exists as a homodimer, archetypal of this chic of enzymes.The homodimeric anatomy of the agitator antiseptic from sus scrofa is apparent in circuitous with the inhibitor carbidopa to the right.

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