The role of tetracain

Tetracain is white powder. It is acrid in water. It is a able analgesic and analgesic agent. analgesic authority than procaine top 10 ~ 15 times, toxicity is 10 ~ 20 times. For the mucosal apparent anesthesia, advice anesthesia, epidural and subarachnoid anesthesia; contemporary anesthesia for Department of Ophthalmology, has the advantages of no corneal epithelial injury, not animated intraocular pressure. Side effects, toxicity, should not be injected into the body; top doses can arrest cardiac advice arrangement and axial afraid system. Tetracaine is a almighty bounded analgesic of the ester group. It is mainly acclimated topically in ophthalmology and as an antipruritic, and it has been acclimated in analgesic anesthesia. In biomedical research, tetracaine is acclimated to adapt the activity of calcium absolution channels ( ryanodine receptors ) that ascendancy the absolution of calcium from intracellular stores. Tetracaine is an allosteric acquaintance of approach function. At low concentrations, tetracaine causes an antecedent inhibition of ad-lib calcium absolution events, while at top concentrations, tetracaine blocks absolution completely.

Tetracaine is actinic from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is accomplished by baking the ethyl ester of 4-butylaminobenzoic acerbic with balance 2-dimethylaminoethanol in the attendance of a baby bulk of sodium ethoxide. bounded anesthetics with lipophilic effect, non dissociative is a all-important activity for assimilation into the nerve, and access the assumption have to change play a role for dissociative answerable cation to. Different bounded analgesic break / non ionic ratios vary. Bounded analgesic than procaine, 10 times greater than that of procaine. Toxicity is greater, 10-12 times greater than that of procaine. Through the mucosa, mainly acclimated for film anesthesia. Quick action, 1 ~ 3 account is effective. Maintain 2-3 hours. Department of Ophthalmology, with 0.5% ~ 1% solution, no austere adverse acknowledgment of corneal injury. 1% ~ 2% band-aid with adenoids and throat, no added than 20ml. The appliance should be in anniversary 3ml add 1 drops 0.1% adrenaline hydrochloride solution. Infiltration anesthesia with 0.025% ~ 0.03% solution, 0.1% ~ 0.3% band-aid with assumption block. Analgesic anesthesia with 10 ~ 15mg and alloyed into the cerebrospinal fluid.

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