Peimisine, the accepted accretion of "zhebeimu" groups and "chuanbeimu" groups, is amenable for the expectorant and ahem abating effects. The aim of this abstraction was to investigate the pharmacokinetics, tissue administering and abolishment of peimisine in macho and changeable SD (Sprague-Dawley) rats by a accelerated and acute LC-MS/MS (liquid chromatography-tandem accumulation spectrometry) adjustment acclimated carbamazepine as the centralized accepted afterwards articulate administration, carbamazepine was declared as an IS. The after-effects showed that peimisine was boring distributed, and alone from rat claret and embodied beeline dynamics in a dosage ambit of 0.26-6.5 mg/kg. Tested by ANOVA, there were gender differences in the pharmacokinetic ambit of AUC0-t, AUC0-∞ a allotment of a individual dosage of 0.26, 1.3, 6.5 mg/kg (P < 0.05). Biologic claret and tissue levels in macho rats were absolutely college than the changeable counterparts afterwards articulate administration, while both the males and the females showed top biologic levels in spleen, kidney, lung, alarmist and heart. On the added hand, the peimisine levels that can be accomplished in uterus, ovary, testis and academician is low. The abolishment abstraction showed that little administered peimisine (<0.7 %) was recovered in the macho and changeable bile. About 13.46 and 15.05 % were recovered in changeable urine and feces, while 43.07 and 7.49 % were recovered in macho urine and feces, respectively, which adumbrated that the above abolishment avenue of macho rats was urine excretion. In addition, there was cogent differences in absolute accumulative excretive arrangement of peimisine in carrion (P < 0.05) and no cogent differences in the urine (P > 0.05) at a dosage of 1.3 mg/kg.
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