Seratrodast for long-term thromboxane A2 receptor antagonist, with inhibition of various chemical neurotransmitter (thromboxane A2, leukotriene D4, platelet activating factor) cause vasoconstriction, and has the inhibition induced by inhaling antigen hairstyle and delayed-type hypersensitivity reaction. Plug qu department cannot immediately release has the onset of asthma, but by eliminating the symptoms of asthma, reduce airway hyperresponsiveness, reduce phlegm, sputum viscosity reduction, strengthen airway cilia clearance ability, so as to effectively curb the emergence and development of asthma.
Seratrodast in Exeter, synthetic reaction bottle to join trimethyl hydroquinone 28.9 g tendency (190), 4. 7 - hydroxy - 7 - benzene heptanoic acid 42.2 g (190 tendency) and toluene 190 ml, under 60 c within 20 min and boron trifluoride ether complexes (57 tendency), 8.1 g and never put off till tomorrow what you can, under the condition of same stir 2 h and then reduced pressure concentration to dry, use leftovers THF300ml dissolved, add 300 ml 1.5 mol/LFeCl3 solution (to) at room temperature, and continue to stir the mixture for 30 min. The reduced pressure concentration, the residues extracted with ethyl acetate 500 ml, extract with salt water washing, drying, the ethyl acetate layer by silica gel chromatography (with) 100 g filter, then wash with ethyl acetate 300 ml silica gel, combined ethyl acetate solution, stress concentration to the dry, leftovers with ethanol recrystallization, plug forrest piece of orange crystal 49.0 g, yield of 73%, the recovery of mother liquor of plug qu department can get 8.4 g, a total of 57.4 g, the yield was 85.3%, mp128 ~ 129 oc.
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