Estradiol transdermal estrogen therapy agent. Supplementary female ovarian secretion of 17-β estradiol deficiency , while avoiding the side effects caused due to oral ( breast pain , weight gain , high blood pressure , gallstones and liver dysfunction , etc. ) . Estrogen can induce cells to synthesize DNA, RNA and associated proteins found in the various tissues .
Clinical significance :
1 . Increase seen in female precocious puberty, gynecomastia , pregnancy ( especially in twins or multiple births ) , tumor secretion of estrogen , ovulation drugs ( such as chlorine Griffin ) , the feminization of men , ovarian tumors, anovulatory dysfunctional uterine bleeding and liver cirrhosis and so on.
2 . Reduction seen in ovarian cancer, mole, intrauterine fetal death , pregnancy-induced hypertension syndrome , hypothalamic tumors, pituitary function of reduced ovarian dysfunction , oophorectomy , delayed puberty , primary and secondary amenorrhea , menopause , oral contraceptive medicine. [ 2 ]
3 , estradiol values increased pathological cause a ) ovarian disorders : ovarian granulosa cell tumor , ovarian germ tumors , ovarian fat-like cell tumors , tumors and other sex hormones , ovarian function showed hyperactivity , increased secretion of estradiol . 2 ) Heart disease: myocardial infarction, angina , coronary artery stenosis. 3 ) Other: systemic lupus erythematosus , cirrhosis, male obesity.
4 , estradiol reduces pathological cause a ) ovarian disease : ovarian agenesis or hypoplasia , primary ovarian failure , ovarian cysts. 2 ) pituitary amenorrhea or infertility. 3 ) Other: A low- or hyperthyroidism, Cushing's syndrome, Addison's disease , cancer, a wide range of infections, renal dysfunction , brain and pituitary of focal lesions , etc., can make plasma estradiol reduce alcohol
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