What is the pharmacological effect of Temsirolimus

What is the pharmacological effect of Temsirolimus? A lot of people probably don't know much about sirolimus, and here's the introduction to it:

Sirolimus (sirolimus) yellow solid, the formula for C51H79NO13, molecular weight is 914.17200, the density of 1.182 g/cm3, melting point is 183-185 ° C, the boiling point of 973.017 DHS C at 760 mmHg, flash point 542.261 DHS C, refractive index of 1.55.

Sirolimus is a new type of large ring lactone class immunosuppressants, white solid crystals, melting point is 183-185 ℃, fatty, soluble in methanol, ethanol, acetone, chloroform and other organic solvents, very slightly soluble in water, hardly soluble in ether. Was developed in the early 1970 s, initially was as low toxicity antifungal drugs, immunosuppressive effects of discovery in 1977, started in 1989 the RAPA as a rejection of the new drug for the treatment of organ transplantation in trial, look from animal experiment and clinical application effect, is a kind of good curative effect, low toxicity, no new immunosuppressant nephrotoxicity. Now frequently as maintain organs for transplant immunity drugs (especially kidney transplant), to slow down the immune rejection of the organ transplant surgery, however, scientists recently discovered another purpose: it can be used in the treatment of alzheimer's disease (senile dementia). To their interest, the main composition of rapamycin in Easter island isolated bacteria in the soil, recent experiments show that the material used in the experimental rats can have ability to restore the memorization defects on the body.