Lithium sulfate, colorless monoclinic crystal or white crystalline powder, soluble in water, insoluble in acetone and ethanol. 25 degrees of water solubility was 25.7%. Alpha, beta, gamma three crystal forms. Alpha model for white monoclinic crystal, beta type as the six-party crystallization, gamma type for cubic crystal. Has the water absorbability. By a lithium sulfate hydrate to crystallize in concentrated aqueous solution is very stable. Have the effect of the treatment of manic depressive psychosis.
Lithium salt can inhibit norepinephrine and dopaminergic nerve endings transmitter release, increase of transmitters reuptake presynaptic membrane, and lower the postsynaptic membrane receptor sensitivity, so as to relieve symptoms. In addition, it also can promote the synthesis of 5 - HT, increase the brain 5 - HT and its metabolites, make the neurotransmitter in the brain to balance. This helps to eliminate the symptoms of affective psychosis, and help prevent recurrence. These changes, may be caused by lithium some electrolytes in the body (calcium, potassium, magnesium) cells inside and outside the change of the distribution, influence the permeability of the neural cells, and the change of the synaptic function.
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