Saquinavir, also known as double sinensis na wei, ShaKui that d, sand sinensis that wei. As the first listed the protease inhibitors for the treatment of HIV/AIDS.
In the cells of HIV infection, HIV protease precursor protein specificity to cracking virus, infectious virus particles can eventually form. Precursor protein loci exist decomposition, these viruses can only be identified HIV protease and its closely related viruses. Saquinavir is a kinds of peptide, structure simulation on this model decomposition site. ShaKui, therefore, that with the active site of the protease HIV - 1 and 2 is right can be closely integrated, in vitro showed reversible and selectively inhibit the activity of protease, and was lower than those of the affinity of human protease about 50000 times.
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